Compound record
Octreotide
SMS 201-995; octreotide acetate (salt form not listed here)
Sequence
dF-CFwKTCT-ol (D-Phe1, D-Trp4, Cys2–Cys7 disulfide, C-terminal threoninol)
FCFWKTCT
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Cyclic octapeptide. Display notation uses lowercase for D-residues and -ol for the amino alcohol terminus.
Notes
Octreotide is a synthetic cyclic octapeptide somatostatin analogue tuned for metabolic stability and preferential SSTR2 activity.
- Retains the Phe-Trp-Lys-Thr motif in a disulfide-bridged core
- Adds D-Phe1 and D-Trp4
- Ends in threoninol (
-ol), a reduced amino alcohol — not a simple amide
| Notation | Meaning |
|---|---|
dF / w | D-residues in display strings |
| Cys2–Cys7 | Disulfide closing the hexapeptide-like core |
-ol | C-terminal threoninol |
| CAS 83150-76-9 | Free-base peptide identity |
Many finished products are octreotide acetate. This database stores free-base formula/MW unless a title says otherwise. Related but distinct: lanreotide (D-2-Nal1, amidated C-terminus).
Primary-source references
- PubChem CID 448601 — octreotide
- CAS 83150-76-9
- Bauer W. et al. SMS 201-995: a very potent and selective octapeptide analogue of somatostatin. Life Sci. 1982.