Compound record
Somatostatin-14
SRIF-14; somatotropin release-inhibiting factor
Sequence
AGCKNFFWKTFTSC (disulfide Cys3–Cys14)
AGCKNFFWKTFTSC
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Cyclic via Cys3–Cys14. The Phe7-Trp8-Lys9-Thr10 β-turn is the pharmacophore exploited by octreotide and lanreotide.
Notes
Somatostatin-14 (SRIF-14) is the classic hypothalamic tetradecapeptide that inhibits GH release and many GI hormones. An N-terminally extended form, somatostatin-28, also occurs in vivo.
A disulfide Cys3–Cys14 closes a 12-residue ring. Inside that ring, the Phe7-Trp8-Lys9-Thr10 β-turn is the pharmacophore later compressed into octreotide and lanreotide.
| Form | Length | Relationship |
|---|---|---|
| Somatostatin-14 (this record) | 14 | Original isolate |
| Somatostatin-28 | 28 | N-terminal extension of SRIF-14 |
| Octreotide / lanreotide | 8 | Engineered analogues, not truncations |
Termini are unmodified on this free-peptide record. Length is 14 residues; the disulfide is a modification, not an extra residue.
Identifiers: CAS 38916-34-6, PubChem CID 16129706, UniProt P61278.
Primary-source references
- PubChem CID 16129706 — somatostatin
- UniProt P61278 (somatostatin, Homo sapiens)
- Brazeau P. et al. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 1973.