Compound record
Glucagon
Glucagon (human); HG-factor
Sequence
HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Linear peptide with a single methionine. Helical in micelles and in the crystal; flexible in dilute aqueous solution.
Notes
Human glucagon is a linear 29-residue peptide from pancreatic α-cells (proglucagon residues 33–61). It raises hepatic glucose output via the glucagon receptor.
Unlike posterior-pituitary nonapeptides, mature glucagon has no disulfide and unmodified termini. The 1-letter string is therefore a complete covalent description for this record.
| Property | Detail |
|---|---|
| Topology | Linear (no ring-closing covalent bond) |
| Length | 29 residues |
| Notable residue | Single Met (oxidation-sensitive in handling) |
| Formula / MW | C153H225N43O49S · 3482.75 |
| CAS / PubChem | 16941-32-5 / 16186314 |
In dilute water glucagon is flexible; in micelles and crystals it populates helix. That conformational behavior is not a database classification flag — only covalent topology is.
Family context
GLP-1 analogues such as exenatide, liraglutide, and semaglutide are evolutionarily related but chemically distinct. Never reuse glucagon’s CAS when documenting incretin mimetics.
Primary-source references
- PubChem CID 16186314 — glucagon
- UniProt P01275 (proglucagon, Homo sapiens)
- Bromer W.W. et al. The amino acid sequence of glucagon. J. Am. Chem. Soc. 1957.