Compound record
Pramlintide
25,28,29-proline-amylin (human); AC137
Sequence
KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2 (disulfide Cys2–Cys7)
KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY
Length
37
residues
Formula
C171H267N51O53S2
elemental composition
Molecular weight
3,949.44
g/mol · average mass
CAS number
151126-32-8
registry ID
PubChem CID
16132446
PubChem ID
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Cyclic N-terminal ring analogous to calcitonin-family peptides.
Notes
Pramlintide is a 37-residue analogue of human amylin with Pro25, Pro28, Pro29 to reduce amyloid propensity while keeping calcitonin-family ring chemistry.
| Feature | Detail |
|---|---|
| Disulfide | Cys2–Cys7 |
| C-terminus | Tyr-NH2 |
| Proline engineered sites | 25, 28, 29 |
| CAS / PubChem | 151126-32-8 / 16132446 |
Do not interchange with unmodified human amylin or with salmon calcitonin — different sequences and registry numbers.
Primary-source references
- PubChem CID 16132446 — pramlintide
- CAS 151126-32-8
- Young A.A. et al. Preclinical pharmacology of pramlintide in the rat. Metabolism 1996.