Compound record
Melittin
Bee venom melittin; MEL
Sequence
GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
GIGAVLKVLTTGLPALISWIKRKRQQ
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Linear amphipathic helix with a proline kink at Pro14 and a basic C-terminal cassette.
Notes
Melittin is the principal 26-residue peptide of honeybee (Apis mellifera) venom: linear, C-terminally amidated, and strongly amphipathic.
A hydrophobic helical face and cationic cassette KRKRQQ-NH2 drive membrane association. Pro14 introduces the characteristic kink seen in crystal and membrane-bound structures.
| Property | Value |
|---|---|
| Length | 26 |
| Topology | Linear + amide |
| CAS / PubChem | 20449-79-0 / 16133649 |
| MW | 2846.46 |
This record is the mature 26-mer, not precursor forms or fluorescent conjugates.
Primary-source references
- PubChem CID 16133649 — melittin
- Habermann E. Bee and wasp venoms. Science 1972.
- Terwilliger T.C., Eisenberg D. The structure of melittin. J. Biol. Chem. 1982.