Compound record
Tetracosactide
Cosyntropin; ACTH(1–24); tetracosactrin
Sequence
SYSMEHFRWGKPVGKKRRPVKVYP
SYSMEHFRWGKPVGKKRRPVKVYP
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Linear 24-mer. The His6-Phe7-Arg8-Trp9 motif is shared with other melanocortin peptides.
Notes
Tetracosactide (cosyntropin) is synthetic ACTH(1–24), the N-terminal corticotrophic fragment that retains steroidogenic activity at MC2 receptors.
The His-Phe-Arg-Trp melanocortin motif sits near the N-terminus. Full ACTH(1–39) adds C-terminal residues absent here.
| Item | Detail |
|---|---|
| Sequence start | SYSMEHFRWGKPVG… |
| Topology | Linear, unmodified |
| CAS / PubChem | 16960-16-0 / 16129627 |
| Precursor context | POMC · UniProt P01189 |
Mass should match a free-base linear 24-mer — no disulfide or amide corrections on this record.
Primary-source references
- PubChem CID 16129627 — tetracosactide
- UniProt P01189 (pro-opiomelanocortin)
- Kappeler H., Schwyzer R. Die Synthese eines Tetracosapeptides mit der Aminosäuresequenz eines hochaktiven Abbauproduktes des β-Corticotropins. Helv. Chim. Acta 1961.