Compound record
Semaglutide
NN1998; Aib8, Arg34, Lys26-Nε-(AEEA-AEEA-γ-Glu-17-carboxyheptadecanoyl)-GLP-1(7–37)
Sequence
H-Aib-EGTFTSDVSSYLEGQAAK(AEEA-AEEA-γ-Glu-C18 diacid)EFIAWLVRGRG
HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRG
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
X denotes 2-aminoisobutyric acid. Lipidation is a side-chain modification, not a backbone insertion.
Notes
Semaglutide extends the liraglutide design: Aib8 resists DPP-4, and Lys26 bears a C18 diacid through a di-AEEA–γ-Glu linker for weekly albumin-bound kinetics.
| Position / feature | Chemistry |
|---|---|
| 8 | Aib (shown as X in 1-letter) |
| 26 | AEEA-AEEA-γ-Glu-C18 diacid |
| 34 | Arg (as in liraglutide-style backbone) |
| CAS / PubChem | 910463-68-2 / 56843331 |
| MW (record) | 4113.58 |
Identity caution: veiled catalog codes used by research suppliers are not proof of this PubChem/CAS entity. Always verify the registry pair above.
Classification remains linear; modifications include lipid-conjugation and unusual amino acid.
Primary-source references
- PubChem CID 56843331 — semaglutide
- CAS 910463-68-2
- Lau J. et al. Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide. J. Med. Chem. 2015.