Compound record
Leuprolide
Leuprorelin; D-Leu6-Pro9-NHEt-GnRH
Sequence
pEHWSY(dL)LRP-NHEt
EHWSYLLRP
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Linear nonapeptide analogue. Ethylamide is a C-terminal modification, not a tenth amino acid.
Notes
Leuprolide (leuprorelin) is a GnRH superagonist: D-Leu6 plus a Pro9 ethylamide instead of Gly10-NH2, yielding a nine-residue peptide with longer plasma half-life than gonadorelin.
| Feature | Detail |
|---|---|
| Length stored | 9 (ethylamide is not a 10th amino acid) |
| N-terminus | Pyroglutamate retained |
| Display cues | dL, -NHEt |
| CAS / PubChem | 53714-56-0 / 657181 |
Depot salts and implants are formulations of this backbone. Compare carefully with goserelin, which keeps a 10th azaglycine amide rather than Pro-NHEt.
Primary-source references
- PubChem CID 657181 — leuprolide
- CAS 53714-56-0
- Fujino M. et al. Further studies on des-Gly-NH210-LH-RH ethylamide. Biochem. Biophys. Res. Commun. 1973.