Compound record
Gonadorelin
GnRH; LHRH; luteinizing hormone-releasing hormone
Sequence
pEHWSYGLRPG-NH2
EHWSYGLRPG
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Linear decapeptide. Position 6 glycine is a hinge; many superagonists substitute D-residues here.
Notes
Gonadorelin is synthetic mammalian GnRH I / LHRH: pEHWSYGLRPG-NH2, matching the endogenous hypothalamic decapeptide.
Position 6 glycine is a conformational hinge. Superagonists such as leuprolide and goserelin remodel this site and the C-terminus for longer action.
| Analogue | Key change vs gonadorelin |
|---|---|
| Gonadorelin (this) | Native decapeptide, Gly6, Gly10-NH2 |
| Leuprolide | D-Leu6, Pro9-NHEt (9-mer ethylamide) |
| Goserelin | D-Ser(tBu)6, Azagly10-NH2 |
Identifiers: CAS 33515-09-2, PubChem CID 638793. Classification: linear with pyroglutamate + amidation tags.
Primary-source references
- PubChem CID 638793 — gonadorelin
- UniProt P01148 (progonadoliberin-1)
- Matsuo H. et al. Structure of the porcine LH- and FSH-releasing hormone. Biochem. Biophys. Res. Commun. 1971.