Compound record
Substance P
SP; neurokinin P
Sequence
RPKPQQFFGLM-NH2
RPKPQQFFGLM
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Linear undecapeptide; C-terminal methionine amide.
Notes
Substance P is an undecapeptide tachykinin (from protachykinin-1) acting mainly at the NK1 receptor in nociception and neurogenic inflammation.
The conserved C-terminal motif FXGLM-NH2 is required for activity. On this record that chemistry appears as a methionine amide; the N-terminus is free arginine.
| Item | Value |
|---|---|
| 1-letter core | RPKPQQFFGLM |
| Display | RPKPQQFFGLM-NH2 |
| Length | 11 |
| CAS / PubChem | 33507-63-0 / 36511 |
Search with the 1-letter core, but reconcile mass using the amide in display notation. NKA and NKB share the C-terminal motif yet are separate sequences.
Primary-source references
- PubChem CID 36511 — substance P
- UniProt P20366 (protachykinin-1)
- Chang M.M., Leeman S.E., Niall H.D. Amino-acid sequence of substance P. Nat. New Biol. 1971.