Compound record
Icatibant
HOE 140; Firazyr (brand; listed only as a synonym)
Sequence
D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg
RRPGGSSXR
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Linear peptidomimetic. Canonical 1-letter code cannot fully represent Hyp, Thi, Tic or Oic; use the display notation.
Notes
Icatibant (HOE 140) is a decapeptide peptidomimetic antagonist of the bradykinin B2 receptor. Multiple positions are non-proteinogenic to improve potency and protease resistance.
Non-canonical monomers (display notation)
| Code | Residue |
|---|---|
| D-Arg | N-terminal D-arginine |
| Hyp | Hydroxyproline |
| Thi | β-(2-thienyl)alanine |
| D-Tic | D-tetrahydroisoquinoline-3-carboxylic acid |
| Oic | Octahydroindole-2-carboxylic acid |
The 1-letter field is only a sketch. Never rebuild formula from twenty canonical residue masses alone. Brand names may appear as synonyms; this site is not a prescribing reference.
Identity: CAS 130308-48-4, PubChem CID 6918173. Topology: linear (no disulfide).
Primary-source references
- PubChem CID 6918173 — icatibant
- CAS 130308-48-4
- Hock F.J. et al. Hoe 140 a new potent and long acting bradykinin-antagonist. Br. J. Pharmacol. 1991.