Compound record
Atrial natriuretic peptide
ANP; ANF; cardionatrin; human atrial natriuretic factor (99–126)
Sequence
SLRRSSCFGGRMDRIGAQSGLGCNSFRY (disulfide Cys7–Cys23)
SLRRSSCFGGRMDRIGAQSGLGCNSFRY
Length
28
residues
Formula
C127H203N45O39S3
elemental composition
Molecular weight
3,080.44
g/mol · average mass
CAS number
85637-73-6
registry ID
PubChem CID
16129705
PubChem ID
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Cyclic 17-residue ring with N- and C-terminal tails of 6 and 5 residues.
Notes
Circulating human ANP is precursor residues 99–126: a 28-mer with a 17-residue ring closed by Cys7–Cys23.
| Region | Residues (approx.) |
|---|---|
| N-terminal tail | 6 residues before the ring |
| Disulfide ring | 17-membered cystine loop |
| C-terminal tail | 5 residues after the ring |
| Termini | Unmodified amine / acid |
BNP and CNP are related natriuretic peptides with different lengths and ring registers. This record is α-human ANP only — CAS 85637-73-6, PubChem 16129705.
Primary-source references
- PubChem CID 16129705 — atrial natriuretic peptide
- UniProt P01160 (natriuretic peptides A)
- Kangawa K., Matsuo H. Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide. Biochem. Biophys. Res. Commun. 1984.