Compound record
Endothelin-1
ET-1; human endothelin-1
Sequence
CSCSSLMDKECVYFCHLDIIW (disulfides Cys1–Cys15 and Cys3–Cys11)
CSCSSLMDKECVYFCHLDIIW
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Bicyclic cystine knot–like pairing. Trp21 is unmodified (free acid).
Notes
Human endothelin-1 (ET-1) is a 21-residue bicyclic endothelium-derived peptide and one of the most potent endogenous vasoconstrictors known.
| Disulfide | Pair |
|---|---|
| Bridge 1 | Cys1–Cys15 |
| Bridge 2 | Cys3–Cys11 |
| C-terminus | Free-acid Trp21 (unmodified) |
The C-terminal hexapeptide is important for ETA/ETB activation. Endothelin-2 and -3 are related but distinct sequences.
Identifiers: CAS 117399-94-7, PubChem CID 16212950, UniProt P05305.
Primary-source references
- PubChem CID 16212950 — endothelin-1
- UniProt P05305 (endothelin-1)
- Yanagisawa M. et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988.