Compound record
Angiotensin II
Ang II; DRVYIHPF; 5-isoleucine angiotensin II
Sequence
DRVYIHPF
DRVYIHPF
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Linear octapeptide. Ile5 is the human/equine residue (Val5 occurs in bovine angiotensin II).
Notes
Angiotensin II is the principal effector of the renin–angiotensin cascade, produced when ACE cleaves His-Leu from angiotensin I.
Human Ang II is an unmodified linear octapeptide: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe. Ile5 is the human/equine residue; bovine material often carries Val5.
| Peptide | Sequence cue | Notes |
|---|---|---|
| Angiotensin I | …His-Leu at C-end | ACE substrate |
| Angiotensin II | DRVYIHPF | This record |
| Angiotensin III | des-Asp1 | Shorter metabolite |
No disulfide, no terminal amide — mass should match a straightforward linear octapeptide free-base calculation (CAS 4474-91-3, PubChem CID 172198).
Primary-source references
- PubChem CID 172198 — angiotensin II
- UniProt P01019 (angiotensinogen)
- Skeggs L.T. et al. The amino acid sequence of hypertensin II. J. Exp. Med. 1956.