Compound record
Bivalirudin
Hirulog; BG-8967
Sequence
dF-PRPGGGGNGDFEEIPEEYL (N-terminal D-Phe)
FPRPGGGGNGDFEEIPEEYL
Length counts residues; formula and mass are the stored free-base values from cited sources; CAS and PubChem identify the substance in public registries. More detail: length & peptide bonds, molecular weight
Structure & modifications
Linear 20-mer. The 1-letter sequence uses F for position 1; stereochemistry is recorded as a D-amino-acid modification.
Notes
Bivalirudin is a synthetic 20-residue bivalent thrombin inhibitor inspired by hirudin: an N-terminal catalytic-site motif, a polyglycine spacer, and a C-terminal exosite I–binding segment.
Stereochemistry that search can miss
Position 1 is D-phenylalanine. The searchable 1-letter sequence stores F; display notation writes dF so chirality is not lost.
| Segment | Role | Sequence cue |
|---|---|---|
| N-terminal tetrapeptide | Active-site engagement | dF-PRP… |
| Polyglycine linker | Spans thrombin surface | GGGG |
| C-terminal acidic motif | Exosite I binding | …DFEEIPEEYL |
Do not confuse bivalirudin with longer hirudin fragments or with heparin’s antithrombin-mediated mechanism. Identity check: CAS 128270-60-0, PubChem CID 16129704.
Classification is linear — there is no disulfide — even though binding is bivalent. Formula and MW refer to the free peptide, not a salt.
Primary-source references
- PubChem CID 16129704 — bivalirudin
- CAS 128270-60-0
- Maraganore J.M. et al. Design and characterization of hirulogs. Biochemistry 1990.